Title | Functional photoacoustic microscopy of pH. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | MR Chatni, J Yao, A Danielli, CP Favazza, KI Maslov, and LV Wang |
Journal | Journal of biomedical optics |
Volume | 16 |
Issue | 10 |
Start Page | 100503 |
Date Published | 10/2011 |
Abstract | pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy. |
DOI | 10.1117/1.3644495 |
Short Title | Journal of biomedical optics |