| Title | Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model |
| Publication Type | Conference Paper |
| Year of Publication | 2010 |
| Authors | S Hu, S Oladipupo, J Yao, AC Santeford, K Maslov, J Kovalski, JM Arbeit, and LV Wang |
| Conference Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Date Published | 02/2010 |
| Abstract | A major obstacle in studying angiogenesis is the inability to noninvasively image neovascular development in an individual animal. We applied optical-resolution photoacoustic microscopy (OR-PAM) to determine the kinetics of hypoxia-inducible factor-1 (HIF-1)-mediated angiogenesis in a transgenic mouse model. During continuous 30-day activation of HIF-1α, we used OR-PAM to monitor alterations in microvasculature in transgenic mice compared to nontransgenic mice. OR-PAM has demonstrated the potential to precisely monitor antiangiogenic therapy of human cancers, allowing for rapid determinations of therapeutic efficacy or resistance. © 2010 Copyright SPIE - The International Society for Optical Engineering. |
| DOI | 10.1117/12.841177 |