Vortex-ultrasound for microbubble-mediated thrombolysis of retracted clots.

TitleVortex-ultrasound for microbubble-mediated thrombolysis of retracted clots.
Publication TypeJournal Article
Year of Publication2023
AuthorsH Kim, B Zhang, H Wu, J Yao, C Shi, and X Jiang
JournalApplied physics letters
Volume123
Issue7
Start Page073701
Date Published08/2023
Abstract

Endovascular sonothrombolysis has gained significant attention due to its benefits, including direct targeting of the thrombus with sonication and reduced side effects. However, the small aperture of endovascular transducers restricts the improvement of their potential clinical efficiency due to inefficient acoustic radiation. Hence, in an earlier study, we used vortex ultrasound with an endovascular ultrasound transducer to induce shear stress and enhance the clot lysis. In this study, the vortex acoustic transduction mechanism was investigated using numerical simulations and hydrophone tests. Following this characterization, we demonstrated the performance of the vortex ultrasound transducer in thrombolysis of retracted clots in <i>in vitro</i> tests. The test results indicated that the maximum lysis rates were 79.0% and 32.2% with the vortex ultrasound for unretracted and retracted clots, respectively. The vortex ultrasound enhanced the efficiency of the thrombolysis by approximately 49%, both for retracted and unretracted clots, compared with the typical non-vortex ultrasound technique. Therefore, the use of endovascular vortex ultrasound holds promise as a potential clinical option for the thrombolysis of retracted clots.

DOI10.1063/5.0155223
Short TitleApplied physics letters