Title | Snapshot Photoacoustic Topography Through an Ergodic Relay for High-throughput Imaging of Optical Absorption. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Y Li, L Li, L Zhu, K Maslov, J Shi, P Hu, E Bo, J Yao, J Liang, L Wang, and LV Wang |
Journal | Nature photonics |
Volume | 14 |
Issue | 3 |
Start Page | 164 |
Pagination | 164 - 170 |
Date Published | 03/2020 |
Abstract | Current embodiments of photoacoustic imaging require either serial detection with a single-element ultrasonic transducer or parallel detection with an ultrasonic array, necessitating a trade-off between cost and throughput. Here, we present photoacoustic topography through an ergodic relay (PATER) for low-cost high-throughput snapshot widefield imaging. Encoding spatial information with randomized temporal signatures through ergodicity, PATER requires only a single-element ultrasonic transducer to capture a widefield image with a single laser shot. We applied PATER to demonstrate both functional imaging of hemodynamic responses and high-speed imaging of blood pulse wave propagation in mice <i>in vivo</i>. Leveraging the high frame rate of 2 kHz, PATER tracked and localized moving melanoma tumor cells in the mouse brain <i>in vivo</i>, which enabled flow velocity quantification and super-resolution imaging. Among the potential biomedical applications of PATER, wearable monitoring of human vital signs in particular is envisaged. |
DOI | 10.1038/s41566-019-0576-2 |
Short Title | Nature photonics |