High-speed photoacoustic microscopy of mouse cortical microhemodynamics.

TitleHigh-speed photoacoustic microscopy of mouse cortical microhemodynamics.
Publication TypeJournal Article
Year of Publication2017
AuthorsL Lin, J Yao, R Zhang, C-C Chen, C-H Huang, Y Li, L Wang, W Chapman, J Zou, and LV Wang
JournalJournal of biophotonics
Volume10
Issue6-7
Start Page792
Pagination792 - 798
Date Published06/2017
Abstract

We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.

DOI10.1002/jbio.201600236
Short TitleJournal of biophotonics