Title | High-speed photoacoustic microscopy of mouse cortical microhemodynamics. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | L Lin, J Yao, R Zhang, C-C Chen, C-H Huang, Y Li, L Wang, W Chapman, J Zou, and LV Wang |
Journal | Journal of biophotonics |
Volume | 10 |
Issue | 6-7 |
Start Page | 792 |
Pagination | 792 - 798 |
Date Published | 06/2017 |
Abstract | We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities. |
DOI | 10.1002/jbio.201600236 |
Short Title | Journal of biophotonics |