Snapshot photoacoustic topography through an ergodic relay for high-throughput imaging of optical absorption

TitleSnapshot photoacoustic topography through an ergodic relay for high-throughput imaging of optical absorption
Publication TypeJournal Article
Year of Publication2020
AuthorsY Li, L Li, L Zhu, K Maslov, J Shi, P Hu, E Bo, J Yao, J Liang, L Wang, and LV Wang
JournalNature Photonics
Volume14
Issue3
Start Page164
Pagination164 - 170
Date Published03/2020
Abstract

© 2020, The Author(s), under exclusive licence to Springer Nature Limited. Current embodiments of photoacoustic imaging require either serial detection with a single-element ultrasonic transducer or parallel detection with an ultrasonic array, necessitating a trade-off between cost and throughput. Here, we present photoacoustic topography through an ergodic relay (PATER) for low-cost high-throughput snapshot wide-field imaging. Encoding spatial information with randomized temporal signatures through ergodicity, PATER requires only a single-element ultrasonic transducer to capture a wide-field image with a single laser shot. We applied PATER to demonstrate both functional imaging of haemodynamic responses and high-speed imaging of blood pulse wave propagation in mice in vivo. Leveraging the high frame rate of 2 kHz, PATER tracked and localized moving melanoma tumour cells in the mouse brain in vivo, which enabled flow velocity quantification and super-resolution imaging. Among the potential biomedical applications of PATER, wearable devices to monitor human vital signs in particular is envisaged.

DOI10.1038/s41566-019-0576-2
Short TitleNature Photonics