Photoacoustic microscopy: principles and biomedical applications.

TitlePhotoacoustic microscopy: principles and biomedical applications.
Publication TypeJournal Article
Year of Publication2018
AuthorsW Liu, and J Yao
JournalBiomedical engineering letters
Volume8
Issue2
Start Page203
Pagination203 - 213
Date Published05/2018
Abstract

Photoacoustic microscopy (PAM) has become an increasingly popular technology for biomedical applications, providing anatomical, functional, and molecular information. In this concise review, we first introduce the basic principles and typical system designs of PAM, including optical-resolution PAM and acoustic-resolution PAM. The major imaging characteristics of PAM, i.e. spatial resolutions, penetration depth, and scanning approach are discussed in detail. Then, we introduce the major biomedical applications of PAM, including anatomical imaging across scales from cellular level to organismal level, label-free functional imaging using endogenous biomolecules, and molecular imaging using exogenous contrast agents. Lastly, we discuss the technical and engineering challenges of PAM in the translation to potential clinical impacts.

DOI10.1007/s13534-018-0067-2
Short TitleBiomedical engineering letters