Title | Handheld optical-resolution photoacoustic microscopy. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | L Lin, P Zhang, S Xu, J Shi, L Li, J Yao, L Wang, J Zou, and LV Wang |
Journal | Journal of biomedical optics |
Volume | 22 |
Issue | 4 |
Start Page | 41002 |
Date Published | 04/2017 |
Abstract | Optical-resolution photoacoustic microscopy (OR-PAM) offers label-free <italic<in vivo</italic< imaging with high spatial resolution by acoustically detecting optical absorption contrasts via the photoacoustic effect. We developed a compact handheld OR-PAM probe for fast photoacoustic imaging. Different from benchtop microscopes, the handheld probe provides flexibility in imaging various anatomical sites. Resembling a cup in size, the probe uses a two-axis water-immersible microelectromechanical system mirror to scan both the illuminating optical beam and resultant acoustic beam. The system performance was tested in vivo by imaging the capillary bed in a mouse ear and both the capillary bed and a mole on a human volunteer. |
DOI | 10.1117/1.jbo.22.4.041002 |
Short Title | Journal of biomedical optics |