Handheld optical-resolution photoacoustic microscopy.

TitleHandheld optical-resolution photoacoustic microscopy.
Publication TypeJournal Article
Year of Publication2017
AuthorsL Lin, P Zhang, S Xu, J Shi, L Li, J Yao, L Wang, J Zou, and LV Wang
JournalJournal of biomedical optics
Volume22
Issue4
Start Page41002
Date Published04/2017
Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) offers label-free <italic<in vivo</italic< imaging with high spatial resolution by acoustically detecting optical absorption contrasts via the photoacoustic effect. We developed a compact handheld OR-PAM probe for fast photoacoustic imaging. Different from benchtop microscopes, the handheld probe provides flexibility in imaging various anatomical sites. Resembling a cup in size, the probe uses a two-axis water-immersible microelectromechanical system mirror to scan both the illuminating optical beam and resultant acoustic beam. The system performance was tested in vivo by imaging the capillary bed in a mouse ear and both the capillary bed and a mole on a human volunteer.

DOI10.1117/1.jbo.22.4.041002
Short TitleJournal of biomedical optics