High-speed Photoacoustic Microscopy

We have also contributed to improving the imaging speed of photoacoustic microscopy. The low imaging speed in photoacoustic imaging has been the limiting factor in dynamic studies, especially functional brain study. Using novel scanning mirrors (e.g., MEMS, polygon), we are developing fast functional photoacoustic microscopy that can achieve an imaging speed of 1 MHz (A-line) and 2 kHz (B-scan) for brain imaging.

Selected Recent Publications:

  1. Zhu, X., Huang, Q., DiSpirito, A., Vu, T., Rong, Q., Peng, X., Sheng, H., Shen, X., Zhou, Q., Jiang, L., Hoffmann, U., & Yao, J. (2022). Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy. Light, science & applications, 11(1), 138.
  2. Zhu, X., Huang, Q., Jiang, L., Nguyen, V. T., Vu, T., Devlin, G., Shaima, J., Wang, X., Chen, Y., Ma, L., Xiang, K., Wang, E., Rong, Q., Zhou, Q., Kang, Y., Asokan, A., Feng, L., Hsu, S. D., Shen, X., & Yao, J. (2024). Longitudinal intravital imaging of mouse placenta. Science advances, 10(12), eadk1278. https://doi.org/10.1126/sciadv.adk1278
  3. Taboada, C., Delia, J., Chen, M., Ma, C., Peng, X., Zhu, X., Jiang, L., Vu, T., Zhou, Q., Yao, J., O'Connell, L., & Johnsen, S. (2022). Glassfrogs conceal blood in their liver to maintain transparency. Science (New York, N.Y.), 378(6626), 1315–1320. https://doi.org/10.1126/science.abl6620