High-speed Photoacoustic Microscopy

We have also contributed to improving the imaging speed of photoacoustic microscopy. The low imaging speed in photoacoustic imaging has been the limiting factor in dynamic studies, especially functional brain study. Using novel scanning mirrors, we are developing fast functional photoacoustic microscopy that can achieve an imaging speed of 100 kHz for brain oxygenation imaging. 

  1. J. Yao, Huang, C.-H., Wang, L., Yang, J.-M., et al., “Wide-field Fast-scanning Photoacoustic Microscopy Enhanced by a Water-Immersible MEMS Scanning Mirror”, Journal of Biomedical Optics, 2012. 17(8): p. 080505.
  2. J. Yao, Lidai Wang, Joon-Mo Yang, Konstantin I. Maslov, Terence T. W. Wong, Lei Li, Chih-Hsien Huang, Jun Zou, Lihong V. Wang, ‘High-speed Label-free Functional Photoacoustic Microscopy of Mouse Brain in Action’, Nature Methods, 12(5), 2015, p. 407-413.
  3. [L Lin, J Yao], R Zhang, CC Chen, CH Huang, Y Li, L Wang, W Chapman, Jun Zou, Lihong V Wang, ‘High-speed photoacoustic microscopy of mouse cortical microhemodynamics’, Journal of biophotonics, 2017, 10 (6-7), 792-798
  4. Wei Liu, Yuan Zhou, Mengran Wang, Lei Li, Emelina Vienneau, Ruimin Chen, Jianwen Luo, Chris Xu, Qifa Zhou, Lihong V Wang, J Yao*, ‘Correcting the limited view in optical resolution photoacoustic microscopy, Journal of Biophotonics, 2017, in press